BEHAVIOR OF SOLVENT-EXPOSED HYDROPHOBIC GROOVE IN THE ANTI-APOPTOTIC BCL-XL PROTEIN: CLUES FOR ITS ABILITY TO BIND DIVERSE BH3 LIGANDS FROM MD SIMULATIONS.

Bcl-XL is a member of Bcl-2 family of proteins involved in the regulation of intrinsic pathway of apoptosis.Its overexpression in many human cancers makes it an important target for anti-cancer drugs.Bcl-XL interacts with the BH3 domain of several pro-apoptotic Bcl-2 partners.This helical bundle protein has a pronounced hydrophobic groove which act

The article deals with the issues of choosing a redundancy method and the frequency of replacing tractor elements while ensuring the level of operational reliability in agricultural enterprises.It is noted that the operability of the Dryer Drum Slide system is ensured as long as there are reserve elements available to replace the failed main elemen

Cystic renal diseases are a group of Swim Bottom disorders that cause neonatal deaths.Autosomal recessive polycystic kidney disease (ARPKD) is a rare entity which may be associated with liver disorders.Presenting autopsy case was stillbirth in 31 + 1 gestational week.In postmortem autopsy,viewed through the capsule, the renal surface was filled by

Juvenile nasopharyngeal angiofibroma is an infrequent epi-pharyngeal tumor necessitating particular diagnostic and therapeutic procedures in comparison to other Manicure Tool Sets benign epipharyngeal tumors due to its expansive growth tendency.Our retrospective study is aimed at presenting clinical casuistry of the tumor in order to evaluate moder

Abstract Keloid is a dermatofibrotic disease known for its aggressive nature and characterized by pathological scarring, which often leads to disfigurement and frequent recurrences.Effective therapies for keloids are still limited, presumably due to the inadequate comprehension of their aggressive mechanisms.In our study, we examined the unique sce